BIOMOLECULAR INTERACTIONS | PROTEIN AGGREGATION & INTERACTION | SURFACTANT & FORMULATION COMPOSITION ANALYSIS

BIOMOLECULAR INTERACTIONS | PROTEIN AGGREGATION & INTERACTION | SURFACTANT & FORMULATION COMPOSITION ANALYSIS

BIOMOLECULAR INTERACTIONS | PROTEIN AGGREGATION & INTERACTION | SURFACTANT & FORMULATION COMPOSITION ANALYSIS

QUARTZ CRYSTAL MICROBALANCE WITH DISSIPATION (QCM-D)
QUANTIATIVE SURFACE & INTERFACE CONTAMINATION

BIOMOLECULAR INTERACTIONS | PROTEIN AGGREGATION & INTERACTION | SURFACTANT & FORMULATION COMPOSITION ANALYSIS

BIOMOLECULAR INTERACTIONS | PROTEIN AGGREGATION & INTERACTION | SURFACTANT & FORMULATION COMPOSITION ANALYSIS

QUANTITATIVE | REAL-TIME | CHEMICAL & SURFACE INTERACTIONS

QUANTIFY VISCOELASTICITY

BIOMOLECULAR INTERACTIONS | PROTEIN AGGREGATION & INTERACTION | SURFACTANT & FORMULATION COMPOSITION ANALYSIS

BIOMOLECULAR INTERACTIONS | PROTEIN AGGREGATION & INTERACTION | SURFACTANT & FORMULATION COMPOSITION ANALYSIS

QUANTITATIVE | REAL-TIME | CHEMICAL & SURFACE INTERACTIONS

TALK TO OUR TEAM

BIOMOLECULAR INTERACTIONS | PROTEIN AGGREGATION & INTERACTION | SURFACTANT & FORMULATION COMPOSITION ANALYSIS

BIOMOLECULAR INTERACTIONS | PROTEIN AGGREGATION & INTERACTION | SURFACTANT & FORMULATION COMPOSITION ANALYSIS

QUANTITATIVE | REAL-TIME | CHEMICAL & SURFACE INTERACTIONS

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Nanoscale Mass Detection

Quartz Crystal Microbalance with Dissipation  (QCM-D) Experimental Design and Execution­

Nanoscience Analytical designs experiments that measure nanoscale mass changes in real-time, in gaseous, liquid, elevated temperature, and electrochemical environments. We can provide a wide variety of QCM-D sample materials to best mimic your situation.  We monitor both absorption and desorption and the viscoelasticity of the material.

Application Examples:

  • Drug & protein interaction with container/packaging
  • Biomolecule interactions with surfaces
  • Flavor and fragrance intensity evaluation
  • Detergency effectiveness and surface cleanliness
  • Cellular interactions with materials/surfaces
  • Quantitative polymer cross-linking
  • Biomolecular binding kinetics
  • Chromatographic detection
  • Viscoelastic modeling

Experimental Design

We provide comprehensive consultation to understand your problems, define the scope of the project, and establish environmental conditions for your sample. We have experience modeling many different types of systems, and that experience allows us to suggest approaches most likely to reveal relevant information.  Choice of sensor material, potential material modifications, flow-through rate, material compatibility, and ideal concentration are important issues to be considered.

Experiment Set-up and Analysis

Proper execution of the measurements requires baseline calibration and careful monitoring to ensure that relevant data is recorded.  During the design phase, parameters are chosen to illuminate the important processes, which may be modified to obtain the most relevant data.  Sometimes the experiments are an iterative process of slightly modifying the initial parameters until the best data is obtained.  We follow a strict ISO quality program to ensure our measurements are reproducible by any of our staff scientists.

Customized Deliverable Reporting

We provide a customized report translating a large amount of data into properties such as viscoelasticity, mass change, sample thickness, film swelling and degradation, and molecular surface interaction.  This information can be invaluable to understand your processes at the nanoscale.

Sensor Material and Selection

QCM-D measures nanoscale surface interaction using specialized quartz crystal sensors that can be modified with 100s of different materials.  We help you choose a material to minimize cost and maximize the similarity to your application.  We have many standard samples to choose from that are extremely popular, but we can also make custom sensors. We can also modify sensors, for example, adding oil or grease to measure cleaning efficiency.  Review our list of sensors, their applications, and intended model system.

Mimic Environmental Conditions

Our ability to mimic actual environmental conditions has made QCM-D a valuable technique for a large range of applications.  Gas flow, liquid flow, elevated temperatures, and electrochemical environments are possible.  Instrumentation material that make up o-rings and tubing can be changed to make them compatible with a large number of solvents.

Conditions that can be changed during an experiment:

  • Temperature
  • Light Exposure
  • Gas mix
  • Liquid concentration
  • Electrochemistry
  • Flow Rate

Nanoscale Surface Interaction Measurements

Adsorption: Interaction Between Molecular Layers
Detergent Analysis: Swelling and Desorption Rates
Film Swelling: Measures Rigidity, Thickness, and Water Content
Multilayer Molecular Interaction: Analyzing Build-up of Polyelectrolytes
Crosslinking: Quantifying Induced Changes in Viscoelasticity and Thickness
Adhesion: Cellular Attachment

Applications

  • Pollutant Exposure
  • Filtration Interaction
  • Medical Devices
  • Electronics
  • Antifouling and Corrosion Analysis
  • Detergent Cleaning Profiles
  • Fuel Cells
  • Pharmaceuticals and Drug Delivery
  • Fundamental Electrochemistry
  • Molecular Biology & Anti-body Analysis
  • Biofilm and Thin Film Properties

Popular Nanoscale Mass Analysis Services:

  • Thin Film Degradation
  • Formula or Sample Stability
  • Sample Cleaning Profile or Desorption Rate
  • Protein-Protein Interaction
  • Protein-Surface Interaction
  • Sample or solution Structural Changes
  • Degradation of Polymer Coatings for Flavor Profiles

Questions about Nanoscale Mass Detection?

Contact us for additional QCM-D services.