electrospinning services
ELECTROSPINNING SERVICES

POLYMER SELECTION & BIOMATERIAL CONSULTATION | PROCESS DEVELOPMENT & DESIGN CONSULTATION | PROOF OF CONCEPT PROTOTYPING

POLYMER SELECTION & BIOMATERIAL CONSULTATION | PROCESS DEVELOPMENT & DESIGN CONSULTATION | PROOF OF CONCEPT PROTOTYPING

POLYMER SELECTION & BIOMATERIAL CONSULTATION | PROCESS DEVELOPMENT & DESIGN CONSULTATION | PROOF OF CONCEPT PROTOTYPING

PROCESS DEVELOPMENT WITH ELECTROSPINNING
PROCESS DEVELOPMENT WITH ELECTROSPINNING AND ELECTROSPRAYING

CALL TODAY FOR CONCEPT DESIGN CONSULTATION WITH AN EXPERT TO ENSURE THE SUCCESS OF THE END PRODUCT. WHETHER IT IS CONSULTATION OR MATERIAL ANALYSIS FOR PROTOTYPE DEFECTS, HAVING THAT DATA ENSURES YOUR COMPANIES’ VISION SUCCESSFULLY REACHES THE NEXT PHASE.

CALL TODAY FOR CONCEPT DESIGN CONSULTATION WITH AN EXPERT TO ENSURE THE SUCCESS OF THE END PRODUCT. WHETHER IT IS CONSULTATION OR MATERIAL ANALYSIS FOR PROTOTYPE DEFECTS, HAVING THAT DATA ENSURES YOUR COMPANIES’ VISION SUCCESSFULLY REACHES THE NEXT PHASE.

CALL TODAY FOR CONCEPT DESIGN CONSULTATION WITH AN EXPERT TO ENSURE THE SUCCESS OF THE END PRODUCT. WHETHER IT IS CONSULTATION OR MATERIAL ANALYSIS FOR PROTOTYPE DEFECTS, HAVING THAT DATA ENSURES YOUR COMPANIES’ VISION SUCCESSFULLY REACHES THE NEXT PHASE.

scanning electron microscope(SEM) Expert Zachary Gray Ph.D.
TALK TO OUR EXPERTS

OUR TEAM HAS UNMATCHED EXPERIENCE WITH NANOPARTICLE & NANOFIBER SYNTHESIS. WITH YEARS OF CLIENT INSTRUCTIONAL TRAINING AND PROOF OF CONCEPT CONTRACTS, OUR TEAM IS MORE THAN HAPPY TO PROVIDE OVER THE PHONE CONSULTATION FOR YOUR CONTRACT SERVICE NEEDS.

OUR TEAM HAS UNMATCHED EXPERIENCE WITH NANOPARTICLE & NANOFIBER SYNTHESIS. WITH YEARS OF CLIENT INSTRUCTIONAL TRAINING AND PROOF OF CONCEPT CONTRACTS, OUR TEAM IS MORE THAN HAPPY TO PROVIDE OVER THE PHONE CONSULTATION FOR YOUR CONTRACT SERVICE NEEDS.

OUR TEAM HAS UNMATCHED EXPERIENCE WITH NANOPARTICLE & NANOFIBER SYNTHESIS. WITH YEARS OF CLIENT INSTRUCTIONAL TRAINING AND PROOF OF CONCEPT CONTRACTS, OUR TEAM IS MORE THAN HAPPY TO PROVIDE OVER THE PHONE CONSULTATION FOR YOUR CONTRACT SERVICE NEEDS.

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Electrospinning Technique

Electrospinning is a voltage-driven technique governed by the electrohydrodynamic phenomena where fibers are made from a polymeric solution. The polymer solution is typically pumped through a nozzle at a constant flow rate and a specific voltage is applied to create an electric field between the nozzle and a fiber collector.

Once the surface tension is overcome due to charge accumulation, a solution jet is ejected and due to bending instabilities and whipping motion the solvent evaporates and a solid fiber is formed. Fiber diameter can range between tens of nanometers to a few micrometers according to solution, processing and environmental conditions. Advantages like surface area to volume ratio, ease of active pharmaceutical ingredient (API) encapsulation, operation at room temperature, among others, make this technique ideal for multiple applications from R&D to field applications with batch-to-batch consistency.

Coaxial Electrospinning & Electrospraying

Coaxial electrospinning and electrospraying are ideal for creating novel nanofiber and particle synthesis. Microencapsulation is a unique encapsulation method, that unlike spray drying, is conducted at room temperature allowing for thermolabile active ingredients to be processed. Microencapsulation is the process we use to generate core-shell fibers and/or particles. The inner structure is surrounded by a coating, forming a small fiber or particles of an active substance with a uniform shell. It can be designed to have, for example, microporous and semi-permeable properties around it. We can generate core-shell structures (fibers or particles) along with a secondary fiber or particle during the same electrospinning process.

Emulsion Electrospinning

Emulsions can create core shell or composite fibers without modification of the emitters. However, the emulsion fibers are more difficult to produce than coaxial electrospinning due to an increase in variables of the technique. To create an emulsion fiber a water phase and an immiscible solvent phase are mixed in the presence of an emulsifying agent. An agent that stabilizes the interface between the immiscible phases is required. After the emulsion formula is optimized, the emulsion droplets within the fluid are stretched and gradually confined leading to their coalescence during the electrospinning process.

Dual Polymer Solution Electrospinning

Advance applications require advance capabilities. Each polymer has desired properties — one polymer degrades faster than the other, releases a drug faster, is used as a sacrificial material to improve porosity, among others — that have variables that influence the electrospinning process and the success of the final product. When creating a combination of either fiber A-fiber B, fiber-cells or fibers-particles relative humanity and temperature.

Challenges of Electrospinning Nanofibers and Electrosprayed Particles: Relative Humidity and Temperature Conditioning

Environmental conditions are critical to nanofiber production. The environmental conditions that influence the electrospinning process the most is temperature and more crucially relative humidity. During the electrospinning process, if these conditions are not monitored or accounted for the morphology of the fibers or particles are greatly influenced. The needle can accumulate a ‘build-up’ of fibers signifying the environments influence on the spinning process. Controlling relative humidity and temperature may require trial and error and may need to be adjust on a daily basis to control the morphology of a final product and obtain reproducible results.

Electrospinning Nanofibers: Needle-less versus Needle-based

Needle-less Electrospinning: When using a needle-less method, the starting polymer solution is transferred to an open vessel. The fibers are generated from a stationary or rotating platform. Mass production of final product is one benefit in the needle-less electrospinning process. However, fiber morphology and consistency become difficult to reproduce and control. Fiber morphology, orientation, and quality are not precisely controlled.

Needle-based Electrospinning: When using the needle-based method, the starting polymer solution is typically contained in an air-tight closed reservoir. This reservoir minimizes and prevents solvent evaporation — preventing evaporation before the process starts encourages consistent fibers. The needle-based electrospinning method increases control over morphology and capability. Different structures and fiber properties like core-shell, multi-axial fibers, dual solutions, blended polymers solutions, specific fiber orientation, and porosity for desired scaffolding can be controlled and reproducible.

More control over the process with the needle-base electrospinning method allows for active pharmaceutical ingredients (API) to be incorporated within a fiber and bone and tissue scaffolds to developed. Other advantages of needle-based electrospinning are focused on controlling the product during the spinning process by controlling flow rate and polymer-solution control.

Synthetic Polymers:

  • Nylon
  • Poly(e-caprolactone) (PCL)
  • Poly(lactic-co-glycolic acid) (PLGA)
  • Polyacrylonitrile (PAN)
  • Poly(ethylene terephthalate) (PET)
  • Polyglycolic acid (PGA)
  • Polylactic acid (PLA)
  • Polystyrene (PS)
  • Polysulfone (PES)
  • Polyurethanes (PU)
  • Polyvinyl alcohol (PVA, PVOH)
  • Polyvinylidene fluoride (PVDF)
  • Polyvinylpyrrolidone (PVP)

Natural Polymers:

  • Cellulose
  • Chitosan
  • Collagen
  • Gelatin
  • Levan
  • Starch

Additives (metals, ceramics, bioactives, and other small molecules):

  • Aluminum
  • Gallium nitrate hydrate (Ga(NO3)3)
  • Platinum
  • Titanium
  • Zinc
  • Zirconium hydride
  • Hydroxyapatite (HA)
  • Asphaltene
  • Hyaluronic Acid
  • Lecithin
  • Myoglobin
  • Hemoglobin

*Other materials available upon request. Please contact us for more polymer materials

Questions about Electrospinning/Spraying Techniques?

Contact us for additional electrospinning/spraying capabilities as well as formulation and process development.